Returnal

1. Go to settings and turn on automatic running.
2. Turn on auto-aim to the maximum level.
3. Going through the first location in each of the two acts is the most difficult thing in the game, so take death easier at first. Just study the enemies, their habits, attacks, then before you know it, you’ll get used to it. In the next two biomes, you will retain all your leveling, it will be much easier, but you should not relax, otherwise you will start again from the very first one. Although this is useful for achieving achievements for visiting the house completely (6 times), and getting the secret ending (act 3), it is better to read the description of these trophies. After the first act (1-3 biomes) there will be a save.
4. Try to completely clear all the rooms, this way you will get new artifacts and equipment that may stay with you forever. Although complicated arenas (yellow gates with a star) are better left for the end of the level, when you have already leveled up, as well as revenge for the scouts. When you have cleared everything, you can go to the boss, although after it you can teleport around the level; there is enough backtracking in the game. If you see that you can’t cope with the enemies, go out to the previous, cleared arena, if the doors are not blocked, and go back there. Well, of course, walking on lava, swimming underwater, hanging on a hook, and the like will only be available as you advance and kill bosses.
5. Spend ether only on points of reincarnation (rebirth) 6 pieces, in the future there will be an artifact that gives a bonus to protection for having ether, the more pieces, the greater the percentage of protection. I do not recommend opening chests and cleaning other items for him. Maximum open where the probability of failure is moderate without air. Sometimes there are really not enough keys, I sometimes cleaned them.
6. The game has a clever way to increase HP, when you find or buy an artifact that gives an increase in the strength of the spacesuit, for attaching/detaching parasites, you can collect them all after clearing the level, then remove them in a special machine - it appears on the first or second level, after victory over the boss, then randomly. This way you can quickly gain a maximum of 300% HP.
7. There are very useful artifacts: an astronaut - revives after death, there is the same parasite, but a compartment with two malfunctions. Vampirism - increases HP by increasing adrenaline levels. An artifact that restores HP when it is low, increasing defense and damage, with the same symptoms. Well, always try to spend money on improving HP, damage, and defense. Also a very good thing is an increase in damage; at 30% of the enemy’s HP, they simply explode.
8. For guns in the first act, I would advise using a carbine (1 biome) and a void machine gun (2-3 biomes). Taking a laser (empty beam) and an electric beam (energy flow) from alternative fire hits bosses very powerfully, and most importantly, not just once, but for a long time. I even like electricity more than laser, although the latter was praised more here. But the damage in both cases is colossal. In the second act, it will be possible to upgrade alternative fire to the second level and weapon bonuses, well, depending on your luck. In the fourth biome, at first I ran with a machine gun, but then a good energy barrier cannon will appear. She is very good against normal and average mobs, because... you can shoot and hide, and the damage will drop on its own, or you can place protective threads near you and the enemies will bump into them themselves. The weapon is good for mobs, and not for bosses and mini-bosses, but moving on a hook will help you until the alternative fire is restored, you can do it with this gun. At the end of the fourth biome, a carbine with leeches fell out (recovery of HP when hitting an enemy), coupled with adrenaline vampirism you become practically invulnerable. Of course, I sometimes picked up other guns, higher up the level, all sorts of rot spitters, rocket launchers, boomerang shells, etc. But given the high complexity, I almost always returned to the main three guns: a carbine, a void bomber and an energy barrier. There is no time for mistakes and running-in, so I used reliable ones. Although I think you can pass with the rest if you have sufficient qualifications. If you, like me, go at a rush and don’t die after the first biome until the end of the act, then the skill level of the guns will always be at the maximum by the last biome and it will become an easy walk. The main thing is to survive the first bomb of each act.
9. In the game you can farm oboliths in the fourth biome. As we already wrote above, you need to reach the end of the level, when you need to go up to the boss and at the bottom of the arena chop with a sword the roots (branches) sticking out of the ground, in other words, the stems. They are not big and always go in such an arc, three at a time. You clear the first floor, I also went up one, and chop them down. Then you teleport to such a tomb, where one of the two keys to the gate lay, such a dark, rectangular room, and there you also chop branches around the perimeter. Then back to the arena in front of the boss. Those. While you clear one arena, they grow anew in another. In an hour and a half, I bought all the remaining artifacts on the level, and left 2000 oboliths for the fifth biome. If you map out the optimal, fastest route along these branches, then in one go you can cut down 70-130 oboliths in 2 minutes. Also, sometimes large, round plant balls give oboliths and parasites, so always, when running through the levels, cut down both the branches and these balls. In the sixth biome, at the start, do not rush to immediately kill the large octopus, from whose teleport jellyfish endlessly fly out. It’s better to immediately improve your qualifications to level 30 on jellyfish and then you will get good guns throughout the entire level.
Upd: Over time, I came to the conclusion that the rotspit is one of the best weapons. Rot removes the enemy’s HP much faster than the energy barrier and you can also hide, it automatically removes HP. Yes, and small mobs like jellyfish and flying drones only need one shot, unlike the energy barrier. But here you need to decide on your tactics, if you like shelters, then you can’t think of a better weapon, and with a machine gun or carbine you can shoot many opponents on the run. You just need to choose a tactic: speed and damage or cover and accuracy, whichever you like best. Well, it’s true that this weapon is more relevant from the second act, where it is much more powerful 15+.

In general, don't chase the right builds. The best weapon for clearing is Hollowseeker + Portal Beam (1-2) levels on it. If there are also Waves, then you are absolutely in trouble, all the bosses will be happy. The bottom line is that in 4-6 biomes there are robots/jellyfish that have very little HP, there is no point in taking something like rockets to these biomes. This weapon cleans instantly, just like strong mobs (the Portal Beam with auto-targeting and the Waves that the Void spews in the direction of the shot do this for you), while dealing titanic damage.

Unfortunately, all the other weapons and other attachments for the Void seemed weak to me, or I simply did not understand how to assemble them. Please note that the weapon still needs to be upgraded (that is, not the weapon itself, but its parameters. Upgrade the waves and the portal beam.

Having found such a weapon in the 4th biome, even at level 15, you can carry it through the 6th biome with ease without changing it the entire game, but the randomness is built in such a way that, in general, the same exact Void as you have in your hands will fall out at a higher level, the only thing that the levels may change places. For example, portal beam 1 and waves 1 were selected, and now portal beam 2 and waves 1 will be.

If given a choice, it is better to give preference to the portal beam. It damages like hell, plus it hovers on targets.

This is just my opinion, maybe there is a better build.