Bloons TD 5

This will take a very long time to get naturally. A normal game from wave 1 to wave 85 has 277 Leads and there are no Leads after wave 85 so you would have to play about 1,000 games. Please note that there is no visible counter which shows your progress towards this and the other 'pop x bloons' trophies so I can't tell if restarting a mission or exiting mid-wave has any impact on progress. The game saves after every wave so my best guess would be that after every wave, your progress towards these trophies is saved as well.

There are multiple methods to make progress faster than just replaying maps:

1: You can replay the Wizard Lord Special Missions which has about 700 leads. You can play the Special Mission as often as you want and once you've gotten all the upgrades it shouldn't be challenging.

2: Once you have finished all 250 random missions, you can alternatively replay the random mission "Chemical Warfare". In this mission, all bloons with an RBE of less than a lead (i.e. black, Ice, Pink, Yellow, Green, Blue and Red) are Leads. This method is probably more pleasant than the Wizard Lord Special Mission since you don't have to rebuild towers constantly and once your setup is powerful enough you can leave the game run by itself. "RBE" means "Red Bloon Equivalent" and tells you how many Red bloons (which are the weakest kind) the next wave is equal to.

Below, I will show you how to play Chemical Warfare after finishing all 250 random missions. You can also play it multiple times once it first shows up but as explained in the walkthrough for Entirely Random, it's gone once you exit the menu until you all the random missions are complete.

3: This is by far the fastest but also the most difficult method. You can Regen farm wave 14 in the Wizard Lord Special Missions. This wave has Regen Lead bloons and if you manage to keep them multiplying the trophy will pop after an hour or two. In order to efficiently farm you must keep the balance. If you eliminate too many bloons you will eventually finish the level and your farming is over. If your setup is unbalanced, this usually happens within the first ten minutes. You must also avoid the opposite because the game becomes extremely slow if too many bloons are on screen and eventually you won't be able to move the cursor anymore or execute any actions.

I have used a method similar to Angel Krienstovich's but I couldn't get his setup working so I made some modifications and ended up with a 4/2 Dartling Gun, a 1/3 Glue Gunner and two 3/0 Ice Towers. Until I was able to afford a 4/2 Dartling Gun I used two 3/1 Boomerang Throwers which I upgraded to 4/1 once I could afford it. I recommend to fully upgrade the Dartling Gun speciality building and activate it when trying this method since you can then lock your Dartling Gun to a target, otherwise it'll follow the cursor.

The purpose of the Ice Towers is to slow down the bloons near the Wizard Lord so he always has enough bloons available to push back to the beginning of the map where they get glued (no corrosive glue!). The Dartling Gun makes sure no bloon gets through to the end of the map. The positions of the Ice Towers and the Dartling Gun's ray are important because the slow down area must be just big enough to keep the pool of bloons healthy (or else the Wizard Lord will destroy them too quickly and finish the wave) but not too big or otherwise the game gets too slow.

The trophy will only pop once you finish the level so you must find a way to finish farming. I just placed a second 4/2 Dartling Gun and aimed it at the entrance. The trophy popped for me after wave 15 so don't be surprised if it takes a little while.

You can see in the following video how I survived the first 12 waves but I setup my towers in wave 13 and started farming in wave 14. I have recorded the first 30 minutes as proof that this setup is stable but there is no need to watch more than the first 5 minutes otherwise.