Curse of the Dead Gods

This does not require a run to be completed. The achievement unlocks immediately upon making the 10th blood offering.

I set out with the sole purpose of getting this achievement, so I equipped the Will of Sich'al blessing that gives you 600 total curse points instead of 500. I also took T'amok's Bones for some extra health as I was avoiding all healing rooms. I checked the area map before setting off, as most players probably do, and picked a path on each section with the most altars. I had to select 2 question marks and only one had an altar, the other was a challenge room, but it seems that it's entirely possible to get 10 altars prior to the 2nd boss. As one of my rooms was a challenge room I had to beat the 2nd boss to get to the next altar, so I would recommend picking the area you're most comfortable with.

Finally, I picked the cheapest upgrade at each altar until I absolutely knew that I wouldn't reach the curse cap. Even if it is a weapon you don't want you can just pick up the previous weapon you hsd, which will be lying on the floor at the altar.