Mafia II

Story related, can't miss it.

This chapter is relatively short. it ends after you steal a car for Mike Bruski, and take Joe home. When you go to sleep on his kitchen couch, the achievement will pop.

Not missable

Chapter 2: Home Sweet Home

Protecting the Family

Joe will drop you off at your mother's place. Enter and spend the night. In the morning you'll discover that the family owes money to a loan shark. One of the enforcers shows up and harasses Francesca. Defend your sister by brawling the goon.

You should mostly hold down the dodge button so you can avoid every enemy hit, making you invincible. After the mobster takes a swing, quickly throw a counter punch to easily hurt him. Use heavy assaults to brutally harm him. Finally, end the fight with a bloody finishing move. With Francesca saved, head to Joe's.

Car Jacking

If you're still hurting from the fight, take some food from Joe's fridge to replenish your meter to full. While you recover life over time, you can never bring the health gauge to maximum without food.

After meeting with Joe, get into his car and follow the waypoint on your map. Joe will pay for a lock pick, allowing you to open locks discreetly. Push on the lock's pins and when they turn green, use the wrench to secure them into place.

You can try out the lock pick in the store before using it out in the open. When ready, leave the building and steal the car nearby. A cop will notice so you'll have to drive out of their range. Next, take the car to your next waypoint to change plates and give it a new color. This will make the car unrecognizable to the police.

Favor for Mike

With your new ride, take it to your next way point: Mike's junkyard. Here's you'll gain a handgun and your first job. Mike wants you to steal another specific car. Before leaving, test out the gun by destroying one of mike's old vehicles. You'll be supplied with extra ammo, so feel free to go nuts.

When ready, follow the waypoint and arm yourself. Hop the fence and shoot the guy on the other side. Your gun is powerful enough to kill foes with a well placed headshot. Take cover and shoot any other gang members that show up. After cleaning the initial three, steal the car and rush out.

Several more enemies will appear: some on foot, but others will chase after you in a car of their own. Speed away fast, but avoid being caught by the cops. If the enemy gang manges to run into the cops, they will be arrested, leaving you free. Either way, take the car to Mike to recieve your reward.

A Honest Job

Head back to Joe's and rest for the night. In the morning head to the docks and take a job with Derrick. Your task is to move boxes into the back of a truck. However, there is no reward and you'll automatically give up after some time. Whenever you want, exit the dock warehouse.

You'll be given a new job of extorting money from the dock workers. Go up and talk to each worker. Most of them will hand over their money without fuss. However, some will fight back. In these cases, beat them down with a few punches until they give in.

After taking cash from three workers, Bill will pick a fight with you. Take him down with the standard melee strategy. Dodge until he throws a punch, counter with a quick attack, and finish him off. With the job done, collect your cut from Derrick and head home to complete the chapter.

Source: http://www.gamespot.com/features/6274410/p-3.html