MLB 10: The Show

The hardest trophy in the game. It's one part skill and one part luck.  

I used Ryan Howard (unedited) in New Yankee Stadium. I know many people prefer Stomp Ground because center is so short, but if you use Howard and have good timing you will hit the majority of your homeruns to right where Yankee Stadium is actually much shorter. For the record I did not hit a single homerun to the left of dead center. Sliders DO affect HRD and here are how mine were set:
USER:
Contact: MAX
Power: MAX
Timing: MAX
Fouls: MIN
Solid Hits: MAX

CPU: (for all the good it does)
Pitcher Control: MAX
Pitcher Consistency: MAX
Strike Frequency: MAX
(For the record I do not believe these three helped me at all, but what can it hurt?)

GLOBAL:
Pitch Speed: MIN
(This one was crucial for me. It slows down the pitches and gives you an extra second to react. This will allow you to judge the truly unhittable pitches and lay off of them (up, up and away, in the dirt, breaking down and in are the four main ones that should be avoided)

All I can say is to be patient. I didn't take many pitches but I took a few. When I got to 22-7 and then made an out I put down the controller and took a few deep breaths, let 4 or 5 go buy then hit four straight before making another out. For the last three I just waited for perfect pitches, hit X and prayed.

For the record I firmly believe that has absolutely no affect. This is a one button game that is 5% timing, 95% luck.

My only other piece of advice is to calm down. I played over 1000 rounds of HRD (including rounds where I made an out right away and restarted) and it always had me throwing stuff. This time I played with a total calm over me. I played about 30 rounds tonight before getting it and was calm the whole time. Try not to jump out of your skin when you start to get to the twenties, it will mess with your timing. Hang in there fellow tortured souls. I wish you all the best of luck!

*Credit to djhoch1226

The most important part of all that is the last paragraph. I couldn't agree more. That is the reason most people fail. After getting this trophy, I have been able to reproduce it several times with ease because my heart rate doesn't increase like it used to.