Oddworld: Stranger's Wrath HD

Story-related. Cannot be missed.
Jo’ Mamma is guarded by a lot of Outlaws, including two Nailers. Some Outlaws are perched on higher levels, so kill these with Fuzzles or Stingbees. As you take them out more Outlaws will spawn, including Semi-Autos, who will spawn in alcoves opposite Jo’s position. Kill the Semi-Autos, but if they drop down to the ground level, you can lure them to you and use a Stunkz to quickly incapacitate them for a live capture. Don’t stand around near Jo’s crane as she will use it to try and crush you.

Once the Outlaws are dealt with, Zappfly the elevator switch and head up to Jo’s level. An electrified rope is stopping you from crossing over to her. There is a Zappfly switch for this on the other side, but Jo will turn the power back on every time. Boombats will quickly knock her out, so fire one or two at her and Zappfly the switch. Quickly jump on the rope and head across. If Jo has woken up by the time you get across, fire another Boombat to knock her out again and then bounty her.