Resident Evil: The Darkside Chronicles

This is story-related and cannot be missed. You will unlock this in the fourth Chapter of the Operation Javier scenario.

At the end of the Chapter, you will battle a ferocious and strong monster, sent by Javier. It's a pretty basic fight; not much strategy is required, but I recommend stocking up on submachine gun ammo beforehand. Use a handgun only until you jump on her back. The battle's practically over after that, because at that time in the fight, Manuela will distract the monster with her singing. The monster is then weak and dies with only a few handgun shots. After the fight, a cutscene will trigger where Manuela discovers that it was actually her mother. Manuela feels responsible for so many deaths, including her mother’s. Soon after, when the game reviews the scores, you’ll unlock the trophy.