Resident Evil: The Umbrella Chronicles

This is story-related and cannot be missed.

You will earn this in the second Dark Legacy side-mission in the Umbrella’s End scenario (the new Russia storyline). All in all, a very easy fight. Shooting the orb on his chest does a fair amount of damage, but hitting the orb on his back makes his health drop twice as fast. You could get over half his health down in one try. His attacks are weak and predictable, on top of that. If you want to make this battle even easier, find your way to the 'treasure trove of weapons' in the maze prior to the battle to bag yourself over 1,000 bullets of machine gun ammo. It'll last you the duration of the fight. Check out Love Those Weapons for details on how to find this place.