Resident Evil: The Umbrella Chronicles

This is story-related and cannot be missed.

You will earn this in the final Mansion Incident chapter (the Resident Evil storyline). At the end of the chapter, you’ll discover the Tyrant was tailing you ever since the labs, and its current aim is to stop your escape. The boss fight can be quite rough as the creature is relentless; it’ll constantly charge towards you and slash you with its left arm, which can really beat you down. He can also take massive leaps and slash downwards, so shoot his left arm in both occurrences. When he picks you up, shoot as much as possible to make him drop you. Soon, you’ll gain access to the Rocket Launcher, so use this to finish him off for good. You’ll unlock the trophy soon afterwards, and will have finished the Resident Evil scenario.