Spider-Man: Edge of Time

Story related and cannot be missed. Anti-Venom is the first boss fight in the game. This fight will actually take place in multiple stages where you'll have to switch between the two Spider-Mans.

First showdown as Amazing Spider-Man:
Phase 1: During this phase, you'll be fighting Anti-Venom like you would against any other enemy. All his attacks can easily be dodged with the Hyper Sense ability. Simply continue attacking and dodging him until he self heals himself back to 100%. Repeat the same attacking and dodging method as before until you're prompted to press the button. Chase after him in to the next area to search for him.

Phase 2: Anti-Venom will negate Amazing Spider-Man's powers so no more Hyper Sense ability to dodge his attacks here. Still, simply continue to attack him and dodge his attacks by web jumping out of the way. Eventually, after you take about 40% of his health meter down, Amazing Spider-Man will attempt to reason with Eddie. During this reasoning attempt you'll have to press the button to dodge his attacks and continue to do so whenever it's prompted to be pressed.

Final Showdown as Spider-Man 2099:
Phase 1: As Spider-Man 2099 nothing really changes here. The only real change is Anti-Venom has a few more attacks up his sleeves now. Simply continue to attack him and dodge his attacks with the Accelerated Decoy and press the prompted button whenever it appears.

Phase 2: After removing some of his chips, the scene will change into another area and Amazing Spider-Man will be attacked by Mutants in the other world. Simply stand in front of a mutant pod and then use the Accelerated Decoy to have Anti-Venom destroy the pods.

Phase 3: This is the final phase of the long battle and nothing has changed here. Simply continue to attack him and dodge his attacks and remove his last chip for the trophy to unlock.