The Last Bounty Hunter

For those who played either Mad Dog title, this trophy is much easier this time around. Many locations feature long strings of targets in fixed locations and fixed order. To get this trophy, you will need to watch out for a Buffalo Skull or Lantern - shooting these will fill your gun with twelve shots. Though there are many opportunities to get this trophy, here is the easiest method:

Play the Cactus Kid Bounty. Eventually, you will come to a shootout in a saloon (your last kill in the saloon will be a guy swinging from a chandelier). Directly after this, there is a shooting sequence in the street. Immediately as this sequence starts, shoot the [Skull/Lantern] on the post in front of the building. You will proceed to see ten consecutive targets in fixed locations and in fixed order (watch out... after the first window kill, an innocent woman will pop out of a window - do not shoot her). The screen will then cut to the rooftop, where you will get two more targets in fixed locations, fixed order, giving you your twelve hits. If you miss or accidentally reload during this streak, just allow yourself to be killed - the last checkpoint is right at the start of the sequence. You get unlimited tries and fixed enemy locations/order. It couldn't be easier unless the enemies were hog-tied on the ground in front of you. Just be careful not to finish the sequence if you ever miss a target.