X-Men: Destiny

Story related and cannot be missed.

This is during Mission 3: Chinatown. Your mutant will have to track a one of Gambit's henchmen and eventually convince the henchmen to give you the package so you can personally deliver it to Gambit yourself. Upon meeting Gambit for the first time he engages you in combat and will serve as a boss fight. Defeat Gambit and the trophy is yours.
 

Boss Fight - Gambit's Attacks:

• Kinetic Energy Cards: Throws kinetic energy poker cards.
• Potential Energy Staff Combo: Standard staff combo attacks
• Potential Energy Charge: Charges at you with stored potential energy in his staff.
• Kinetic Energy Shockwave: After storing potential energy in his staff he release it in a shockwave by jumping in the air and slamming down on the ground.

Phase 1:
This fight is very easy. All you have to do is dodge attacks by pressing the button with any Defensive X-Gene that you have equipped. Then run up to him and simply attack him with your standard combo attacks and dodge away from him if he attempts to attack you with his staff. Eventually, he'll jump up on the roof of a building to simply taunt you.

Phase 2:
This phase is exactly the same as phase 1. Only this time he has three new attacks he'll use against you which are again easily dodged with the button. Continue attacking him until he once again jumps on the roof to taunt you.

Phase 3:
This is the final phase, and there's nothing special to say here since nothing has changed. Continue dodging and attacking him like you've done during phases 1 and 2 and you'll finally defeat Gambit.