Alone In The Dark

There are a number of spots throughout the game where you confront groups of Humanz. I found that the easiest thing to do was find a group in Central Park and run backwards to get them clustered together coming after me and then hit all three with a single explosive bottle shot in midair. Make sure you have some bandages with you because you might have to let them get close enough that you get caught in the blast as well.

I found the easiest place to get a cluster of Humanz together to be the Lakehouse where you find the first Root of Evil in Episode 4 (See Burning Roots).