Aven Colony

This achievement can be earned as early as the first mission. It is cumulative, but it is very simple to get in one mission.

Enhancers are drugs with certain positive side effects. Though some do have negative effects in addition to the positive ones.

You gain access to enhancers by first researching them at a Research Center. A Farm or Greenhouse is needed to grow the plant(s) needed. (Since the plant(s) required are inedible, you will have to click the box to allow you to choose to grow inedible plants.) A Chemical Plant will be required to manufacture them once you have begun to grow the plant(s) needed. Finally you need one or more Enhancer Dispensaries to distribute them to your colonists.

Xenoglow is the easiest and most useful drug to produce as it only requires you to grow one specific type of plant. Plus it only has a positive side effect when used.

Alternatively you may get a trade mission that will require you to trade a certain number of a particular good/resource in return for a certain number of enhancers. You will still need the Dispensaries to distribute them as well as a Trade Hub to import the drugs.

You can't unlock this in Holo-Sim 1 or 2 - you'll need to start in Vanaar, but the training levels are very short and do help you learn to navigate the game so I would recommend them if you were a complete newbie to the game like I was.

You will need to build a Farm and a Greenhouse (under Farming Structures) and them grow Xeno Sage. This is the base ingredient for the drug (enhancer) you are going to produce. Greenhouses can function through the (very frequent) winters so it's worth making sure you have at least one of these. I think it's a 1:1 conversion into the enhancer so once you have 500 of these you can redistribute your workers elsewhere.

At this same time, build a Research Center (under Technology Structures) and select it to research Xenoglow, the enhance we're making. Once this is done you can make this a low priority for your workers and even recycle the centre for a fairly decent amount of nanites - I was struggling with these just before I got the achievement. Doing the 'missions' (building certain structures) will help you have enough to keep building.

At this point, I would build an Immigration Center (under Ships & Vehicles) otherwise you just don't have a big enough population for this to go quickly, and because of this you'll need more accommodation (under Residential Structures). I would build a Geothermal Hub (under electricity), placing it on the toxic looking vent to make sure you have power through the winter, and another water pump. Keep an eye on storage too - you'll likely need another storage module (under Resource Management) if the missions haven't encouraged you otherwise.

Back to the enhancers. Build a Chemical Plant (under Resource Management) and make it a high priority or fill for workers. Make sure to go into the building menu and choose to produce Xenoglow. It's produced in batches of 20. You can check your inventory of either Xeno Sage or Xenoglow at any time by selecting a storage module and then opening the inventory.

As soon as you start manufacturing the enhancers, make sure you build an Enhancer Dispensary (under Services-Related Structures) and again make it a high priority or fill (in the winter, de-prioritise the farms to help with employee management). Open the menu for this building and make sure distributing Xenoglow is selected (I can't remember if it's automatic or not). You can also see in the panel here how much of both the drug and the ingredient is in the colony inventory.

It's then a waiting game. Crank the speed up and try to increase your population to not just fill your buildings but also so there are more people consuming the enhancers. I didn't time my efforts but I think this took about 30 mins once I got started on this mission. I was slowed down by running out of nanite though so keep an eye on that amount.

Happy enhancing!