Dandy Ace

You'll reach Jolly Jolly after the first level of the game.
Only a few of the permanent upgrades are available at the start, the rest will open up after you unlock other items.

The ones that will help you the most in your runs are: Tea Potions, Reshuffle, and the Reward Tent Extra Cards.

Gold Credit 1 - Unlock Cost: 15 Shards
Gold Credit 2 - Unlock Cost: 45 Shards
Gold Credit 3 - Unlock Cost: 150 Shards
Gold Credit 4 - Unlock Cost: 400 Shards

Tea Potion Satchel 1 - Unlock Cost: 5 Shards
Tea Potion Satchel 2 - Unlock Cost: 50 Shards
Tea Potion Satchel 3 - Unlock Cost: 300 Shards
Tea Potion Satchel 4 - Unlock Cost: 600 Shards

Card Recycle - Unlock Cost: 15 Shards
Card Recycle 2 - Unlock Cost: 75 Shards

Reshuffle - Unlock Cost: 150 Shards
Reshuffle 2 - Unlock Cost: 400 Shards

Random Blue Card - Unlock Cost: 75 Shards
Random Pink Card - Unlock Cost: 20 Shards

Reward Tent Extra Card 1 - Unlock Cost: 15 Shards
Reward Tent Extra Card 2 - Unlock Cost: 250 Shards