Darksiders II

This is more of a road map rather than a solution.
Here is a list of the main quest line. Hope this helps!

Video of speed run is by Tahlordson


Find a Way to Save War
Find the Keeper of Secrets
Reach the top of The Dark Fortress (1)
Boss 1 - Ice Giant
Reach the top of The Dark Fortress (2)
Boss 2 - War
Finishing the quest

The Fire of the Mountain
Talk to Alya
Talk to Thane
Find the Cauldron
Help Karn defeat Constructs
Restore the Fire of the Mountain (1)
Restore the Fire of the Mountain (2)
Boss 3 - Gharn
Restore the Fire of the Mountain (3)
Return to Alya

The Tears of the Mountain
Talk to Karn
Find Drenchfort
Restore the Tears of the Mountain (1)
Restore the Tears of the Mountain (2)
Boss 4 - Karkinos
Restore the Tears of the Mountain (3)
Return to the Forge Lands and talk to Alya

To Move a Mountain
Find the Lost Temple
Wake the Construct (1)
Wake the Construct (2)
Boss 5 - Construct Hulk
Wake the Construct (3)
Talk to Eideard

The Heart of the Mountain
Talk to the Keeper
Enter the Foundry
Wake up the Keeper (1)
Wake up the Keeper (2)
Wake up the Keeper (3)
Boss 6 - Corrupted Custodian
Wake up the Keeper (4)
Find the Keeper
Boss 7 - The Guardian

The Tree of Life
Go to the Tree of Life

The Lord of Bones
Find the Eternal Throne (1)
Find the Eternal Throne (2)
Go to the throne room
Talk to the Lord of Bones

The Toll of Kings
Find the entrance to the Gilded Arena
Summon the Arena Champion (1)
Summon the Arena Champion (2)
Boss 8 - Gnashor
Bring the Skull to the Eternal Throne

Phariseer
Find Phariseer's Tomb
Resurrect Phariseer (1)
Resurrect Phariseer (2)
Boss 9 - Phariseer
Finishing the quest

Judicator
Find the Judicator's Tomb
Talk to the Judicator
Find the first Soul
Bring the first Soul
Find the second Soul (1)
Boss 10 - Tormentor
Find the second Soul (2)
Bring the second Soul
Find the last Soul
Boss 11 - Bone Keeper
Boss 12 - Bone Giant
Bring the last Soul
Finishing the quest

Basileus
Find the Psychameron
Survive the Psychameron (1)
Survive the Psychameron (2)
13, 14 - Basileus, Achidna
Take the Lords to the Dead King

The City of the Dead
Go to The City of the Dead
Explore the City of the Dead - beginning
Explore the City of the Dead - western part
Explore the City of the Dead - eastern part
Explore the City of the Dead - return to the western part
Explore the City of the Dead - return to the eastern part
Explore the City of the Dead - upper levels (1)
Explore the City of the Dead - upper levels (2)
Explore the City of the Dead - end
Boss 15 - The Wailing Host
Meet up with The Soul
Return to the Tree of Death
Go through the Angelic portal

Key to Redemption
Find the key in Lostlight
Kill Corrupted Angels
Find Archont

The Rod of Arafel
Go to the Earth
Help Uriel defeat the Swarm
Talk to Uriel
Find the first part of the Rod
Return to Uriel with the first part
Find the second part of the Rod (1)
Boss 16 - Nhoss
Find the second part of the Rod (2)
Return to Uriel with the second part
Find the last part of the Rod
Return to the Crystal Spire

Stains of Heresy
Reach the Citadel
Find the Scribe - beginning
Find the Scribe - eastern part of the Citadel (1)
Find the Scribe - eastern part of the Citadel (2)
Find the Scribe - western part of the Citadel (1)
Find the Scribe - western part of the Citadel (2)
Find the Scribe - northern part of the Citadel (1)
Find the Scribe - northern part of the Citadel (2)
Find the Scribe - end
Boss 17 - Jamaerah the Scribe
Face the Archon
Boss 18 - Archon
Return to the Crowfather
Go to the Shadow's Edge

The Mad Queen
Explore the Shadow's Edge
Find the Mad Queen

The Lord of the Black Stone
Find Samael - beginning
Find Samael - eastern part of the Black Stone
Find Samael - western part of the Black Stone
Find Samael - end
Boss 19 - Samael
Return to the Crowfather

The Well of Souls
Enter the Well of Souls
Boss 20 - Avatar of Chaos