Genesis Alpha One

Not as difficult as it first seems since you can dashboard (hit guide and select game and quit) if you or a clone dies and it will reload from a previous save point.

Before attempting this though I would recommend having done another play thru first where you unlock a good number of the corporations and artifacts as well as become familiar with the threats you will face and how to beat the final boss.

For the starting corporation pick one that gives you a good number of artifact slots, I used the Tier III weapons corporation. For artifacts I would recommend the suit health/armor/speed upgrades and the harvester shield barrier and extra turret.

For your ship design, keep the tractor beam/hangar/refinery and deposits isolated from the rest of your modules as that is where you get most of the threats from. I also kept any of the other crew away from those modules and did all of the beaming and refining manually as well as doing most harvester trips solo. And did frequent sweeps both above and below decks to kill any intruders.

Scan the planets and try to find a genesis candidate that only needs 16 crew and then concentrate on getting the biosphere of that type. You can scan adjacent planets on the bridge or assign crew to scan them for you automatically so that can help to find the candidates faster.

You will also want to try and acquire the x-ray caster weapon and get it upgraded to at least tier 2 as I've found that to be the best for taking down the final boss quickly. The parts are dropped by a tall green biped alien that can be found on planets or on your ship with the green algae growth. You can also sometimes find the weapon sold by a merchant.

Once you get the x-ray caster and the required crew for genesis take some turrets and energy shields with you, initiate genesis and go find the spider queen in the cave. You usually know when you are close when you start getting infinite spawning spiders. Then pop down a couple of turrets to kill the smaller spiders, put up a couple of shields then shoot the bubbles on her back with the x-ray caster. Should only take 1 or 2 bursts for each and she should go down quickly.

I killed the boss on the first go so I have no idea if you can dashboard if you die there but I did die or have a clone die 2 or 3 other times while I was exploring or on the ship and I dashboarded and still got the achievement.

If anyone else has any helpful tips, let me know and I can update the solution. Good luck!