Marvel's Midnight Suns

Just to elaborate because the description is not very good.

The villain that needs to be beaten is a ‘fallen’ supervillain I.e Venom, Sabretooth, Crossbones.

I went through my first play through not getting this, trying it on all of the mini super villains late on and nothing.
Second time through on the second story mission with Spider-Man you fight venom outside of a building. The double team card was in my pack from the start of the round. Down him once, then when he gets up, hit him once and then use the double team card to KO him. Popped straight away.

Hope this helps.

This requires you to have heroes in battle, with whom you have a friendship level of at least one, so you can draw the Hero Combo card. Then you need to defeat a villian with that card. That means if you try it during a mission where the villian gets up again, it needs to be for the final life.

If you don't manage naturall during your playthrough then you can easily do it in the THREAT room. Simply set it up in a way were it is very easy and has a villian, then use whichever heroes you have such a card with, weaken the villian, build up four hero points and finish them off.