RESIDENT EVIL 2
44 Achievements
1,070
27-33.5h
A Vault-like Mind
Open a portable safe.
20
47.81%
How to unlock the A Vault-like Mind achievement in RESIDENT EVIL 2 - Definitive Guide
The "dial":
---4-6---
--5---8--
--2---7--
---1-3---
The buttons:
1-2
3-4
5-6
7-8
EDIT - It seems there is no consistency for the solutions, so there seems to be no way to look up a solution online, you'll have to figure it out for yourself.
There are 2 portable safes in the game and to open them you need to select the correct button sequence. This is different for every playthrough, although it is not entirely complicated. You need to light the circle of lights up in order by pressing the 8 buttons in the correct order. An easy way to do this is to look at the pad and number the buttons either in your head or write it down, 1 through 8. Then when you press a button, make a note of which light it illuminates on the circle at the top. Once you know which button corresponds to which light, press them in the correct order to unlock it.
Note both of the portable safe locations are shown in the video in the description for "Lore Explorer" as they are also needed to unlock "Master of Unlocking".