Resident Evil 4

This one deserves a place amid the pantheon of annoying Resident Evil boss fights. First and foremost, make sure you maintain distance from Salazar, or he’ll gobble Leon up in one go and that’ll be that. Wait until the monster’s maw is open, and throw in a heavy grenade if you have one. Failing that, try to shoot the yellow eye on Ramon’s stupid face - he’s inside the creature’s mouth. Keep plugging away and moving, being sure to shoot the exploding pustules he dispenses on the floor, and avoid the stream of acid spit he likes to spew your way, as this inflicts major damage.