Rise of Nightmares

*STORY-RELATED, SO SPOILERS AHEAD!*

This is a pretty straight-forward act, and most of it doesn't even contain any enemies. The hallways filled with blood are the first part with enemies, and I recommend you pick up the Shock Knuckles in the second corridor and use them all the way to the end instead of the Chainsaw in the third part, since you can't block the spitters' attacks while holding that. For the boss, don't run for the blade at the back of the area right away. Instead, wait for him to attack once (usually a quick time event is required to dodge it), and then go. With the Yuli's Blade, just run right up to him and start swinging like crazy. He can take quite a lot of damage, but keep hitting him and he'll go down eventually. His attacks are slow and easily blockable, just watch out for the occasional sound wave (or whatever it is) that pushes you back, usually followed by a chain attack that you'll have to QTE-dodge. Other than that, he shouldn't be a problem, although keep in mind that even just one of said chain attacks will kill you on Torture difficulty.