Rocksmith 2014 Edition

This solution is just some information for those who don't understand how the minigames work. I don't think there is a cool tip that could make it easier.

LEVEL UP - BUILD YOUR SCORE MULTIPLIER !

Even if you aren't very good at this game, play along and level up. You get 'stars' for all kinds of things, so even if you only last a few seconds, you can raise your level.

BUILD YOUR COMBO !

Shoot the bandits in the order they appear, preferably as soon as they appear. If you hit the wrong bandit, you survive but lose your combo, then your scores will be lower.

Pick the strings carefully, so you don't hit the wrong string by accident.

Try playing the strings slightly MUTED, this way the game will register the correct string more easily.

DON'T shoot empty lanes! Not only will you lose your combo, but the bandits will jump forward, speeding up the game and probably causing your early demise.

The bandits tend to come in repeated patterns, the same pattern will usually come twice in a row. Pay attention to those. For example you get this sequence: two red ones, two yellow ones, two blue ones and one big orange one. And then again the same: two red ones, two yellow ones, two blue ones and one big orange one. So pay attention to these patterns, quickdraws will be much easier, bringing you better scores. Thanks to metabolicBatman for pointing it out.

I hope this helps.