Scorn

Non-missable story achievement that pops once you've completed the game - after the end credits in Act V.

Video guide for the full Act and Boss fight:

Here's my 100% Full Game Achievement Walkthrough with commentary showing you how to finish the game in just over 2 hours for those of you who prefer video guides.
Timestamps
Intro 0:00
001 Extraction 1:45
002 Hand in hand 12:50
003 Hazardous occurrence 21:15
004 Close Encounter 30:00
005 Key possession 39:00
006 Path forward constructed 47:10
007 At the lowermost point 1:10.00
008 Station to station 1:19:45
009 Detachment 1:36:25
010 Fluid flowing within 2:04:42
011 Perception Beyond 1:58:00
012 Fin 2:00:00

This full walkthrough with no commentary includes every puzzle solution and every combat encounter in the game, including all cutscenes and the ending.

Timestamps:
0:00:00 - Act 1
0:05:45 - Act 1: Pod Puzzle
0:10:00 - Act 1: Mine Cart Puzzle
0:17:25 - Act 1
0:20:10 - Act 1: Tree Puzzle
0:27:00 - Act 2
0:33:45 - Act 2: Ring Key Puzzle 1
0:34:45 - Act 2
0:37:00 - Act 2: Ring Key Puzzle 2
0:38:00 - Act 2
0:41:00 - Act 2: Ring Key Puzzle 3
0:41:50 - Act 2
0:45:15 - Act 2: Ring Key Puzzle 4
0:46:10 - Act 2
0:47:10 - Act 2: Final Ring Key Puzzle
0:48:20 - Act 2
0:52:55 - Act 3
1:08:25 - Act 3: Node Puzzle 1
1:09:25 - Act 3
1:12:00 - Act 3: Node Puzzle 2
1:13:40 - Act 3
1:29:00 - Act 4
1:46:30 - Act 4: Rotating Maze Puzzle
1:47:20 - Act 4
1:51:10 - Act 5
1:56:25 - Boss Fight
2:05:20 - Act 5
2:17:00 - Act 5: Double Body Puzzle
2:19:50 - Ending

Finish the game. Story based, cannot miss