Slay The Spire

It seems reasonably easy to hit this during a normal Defect playthrough as long as you find "Creative AI". Each time you play a Power you will gain a buff that represents that power. Dexterity/Regen/Speed/Flex/Strength Potions can be helpful too for that last buff if you're short.

After no luck attempting this a few times with The Defect, I got this first try with The Silent. By Act 3 I had amassed a lot of buff cards and one or two potions. Her cards are really tailored for buffs, having all three card types (power, skill, and attack) provide them. I don't believe stacked buffs work here, this has to be 10 unique buffs. The unique buffs and the cards that add them are:

- Deal damage for each card played: A Thousand Cuts
- Bonus Shiv damage: Accuracy
- Gain block for each card played: After Image
- Attacking enemies take damage: Caltrops
- Unblocked damage applies poison: Envenom
- +Dexterity: Footwork
- +1 Shiv each turn: Infinite Blades
- +Poison to enemies each turn: Noxious Fumes
- Draw and discard a card each turn: Tools Of The Trade
- Retain cards each turn: Well Laid Plans
- Block stays through next turn: Blur
- +Block next turn: Dodge and Roll
- +Energy next turn: Doppleganger, Flying Knee, Outmaneuver
- Draw cards next turn: Doppleganger
- Enemy loses HP for each card played: Choke

This combined with potion effects like +Strength and Regen, plus any relic effects, should be more than enough. It was for me.