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As Charon, gain 250 or more max Health from Ferryman of Souls in one game.

Ferryman of Souls is Charon's passive ability. Whenever you're in the assist range of a friendly lane minion or any jungle monster and they die, they'll drop their essence. It will remain in place for 8 seconds. You can pass through their essence and collect it. For every essence collected, you gain 1 gold and 1 soul stack. You can hold up to 20 souls stacks at a time.

Whenever you return to base, the soul stacks are automatically cashed in and you receive a permanent 2 HP buff for every 1 soul stack. Over the course of a game, you can receive a maximum of 350 bonus HP from these soul stacks. For this achievement, you need to reach a minimum of 250 HP, meaning you must collect and cash in at least 125 soul stacks in a single game.

This is best attempted in Slash or Conquest, although any mode would work except perhaps Assault. Build items to increase your protections so you can be on the frontlines near dying minions and be sure to back to the fountain often, especially if you hit your 20 essence limit (your passive icon will state how many you are currently holding).

After you turn in 125 soul essence, you'll gain 250 bonus HP and unlock this achievement.