South Park: The Fractured But Whole

Story related, can not be missed.

At the end of the fourth night, you will have defeat the Kyle 2 Genetic Mutation (AKA Kyle's cousin who has been massively mutated). He is a huge enemy with a ton of health that occupies a large portion of the battle grid. This can make moving around him difficult but it also makes hitting him easier as well. The main issue with the majority of the battle is that he doesn't take a lot of damage normally and does a ton when he attacks. His main attack is where he moves towards a group of your characters, jumps in the air while shoot down a laser from his eyes and then lands on them causing damage to a zone area around where hits causing high damage. After he does that he will start spraying blood out from his nose all over the place which can cause gross out status effects to anyone within it's area. His other attack is where he will bounce across the screen in a straight line smashing your characters for heavy damage. During this time frame you want to attack as much as you can but also focus on healing yourselves so that you do not die from the next attack. Your character is the most important one that needs to survive during this period so keep him alive. Don't use your ultimate yet as you will be better off saving it for a bit.

After a few attacks, he will call for a time out and your team comes together to say you can't defeat him until the sun comes out because his skin can't handle it. Once he says he's ready again, you will be able to use the time change TimeFart to change it to day time by holding and and then pressing up ( + ) on both analogue sticks. When it turns to day, he will begin putting on suntan lotion in order to protect his skin and a meter will appear at the bottom of the screen showing his progress of applying it. During this time his defense will be dramatically weaker and you can do some very high damage to him so go all out on attacking with everything you have and making sure to use your Ultimate as well. Once he finishes applying his sunscreen, the battle reverts back to how it was before with his defense being higher and him doing his attacks. Just keep doing what you did before during this part until you get to the next chance to change it back to night again. When it turns to night, he will stop again to wipe all the sunscreen off and another meter at the bottom will show the progress.

Just keep attacking him and healing yourself as you go through the battle, focusing on doing as much damage as possible during the sunscreen on/off time frames. Once you deplete his energy completely, he will move to the upper right corner and you must do a QTE type thing to finish him off with one last fart. After you finish him and the day/night ends, the trophy will pop.