Spider-Man 3

This is the hardest boss in the game because it simply goes against what most gamers want to do, rush in attacking. With fisk you need to let him strike you, dodge and then beat on him till the first time he blocks then repeat.This process seems slow and lame but its the only way you can survive your tussle with this giant in this closet sized area.

HOW TO BEAT WILSON FISK (IF YOU CAN'T BEAT WILSON FISK)

The other solutions online are helpful and definitely say what I'm about to in less words but I feel like there is a group of players who just can't seem to beat him after many failed attempts because they need more information/details... "what buttons to press and when".

I feel compelled to write a more detailed & up-to-date solution to get back at Fisk for all of the frustration he causes. I can fairly say the following solution should help you beat Fisk within 20 attempts/2 hours.

Do yourself a favour and forget everything you think you know about how "difficult" Wilson Fisk is. He's just tricky. You've likely been button mashing yourself through fights up in the air 100ft until now but this fight requires a bit of finesse because it's in close quarters, on the ground with a really hard hitter. I'm going show you a pattern to follow and hopefully you can beat him in about 7-10m.

Anyways, let's get to what you came here for...
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The fight starts. Get some distance from Fisk & stop moving. You'll see Fisk start moving near or around you. Now, intermittently press LB for your spider senses to kick in - the closer he gets, the longer you hold LB down. I emphasize intermittently because you basically want that effect to be active at all possible times when he is near you so you can dodge his attacks but if you hold it down too long you'll be out of your spidey sense. Now, watch his movements - if he's in your screen he tends to either wander around you OR move directly to you and it's a noticeable difference in the way he walks. He'll come in to attack you and as he does this, that yellow symbol pops up above his head. You have to time it so that you're holding down LB and pressing a direction when that symbol show ups - this is how you dodge his massive blows. I always pressed down when I dodged because I wanted to keep it simple but any direction will do. It doesn't matter which way you're facing or which direction he's coming from - just wait patiently for his attack and make sure to hit that button combo to counter and you'll be good. Spider-man will roll & a blue X pops on the screen when you properly dodge - this is your opportunity to (quickly) counter and get a small amount of damage in on Fisk as well as build up a small amount of rage. It's a short window and something to get used to but you'll get the hang of it. I kept it simple again and always countered with a few fast attacks (X) followed by a jump (A) upwards. Properly done, it should say "COUNTER JAB / 2 HITS" at the top-middle of your screen after you've countered and you should be in the air above Fisk. Jump up for two reasons: 1) Fisk will more than likely follow the counter you are doing with another attack since you are so close and you probably won't react in time, by jumping you'll avoid this. And 2) this fight is about 10 minutes of precisely timed dodges, so this will give you brief moments to take a break and reset yourself in case you get kind of lost as to what's going on (I know I constantly did). Now... fall back down at Fisk's feet and repeat that sequence again. After 4-5 of these "counter-jab, jumps" your rage meter will max out. Immediately leap to the other side of the room to get some distance from Fisk and hit RB a few times to turn on your rage then charge back at him. At this point, I don't really know what attacks would be the most effective so just stick to different combinations of Xs and Ys - trying to get combos of 15-20. While raging out, intermittently press LB again - while most of your rage attacks will hit him, sometimes he'll sneak one in on you and by throwing the occasional LB into the mix of Xs/Ys you can often dodge it. The LB will also slow down time, increasing your attacks per second/damage over time. When your rage is about to end leap back and get your distance again (if you attack him until your rage ends completely he more often than not gets a hit in on Spidey).

Repeat that process until he is dead and you're not. If it helps to give you a sense of timing, how effective the process is and how much room for error there is... after defeating him my very first time, I had raged out 8-10x and 75% my life remained.

It's also worth mentioning...
That I never really pressed LT, RT or B. I also continually centered the camera so that nothing obstructed my vision. Occasionally the fight will start and you'll have a full rage meter that you can activate immediately - go a little harder if that happens because that might be what does it for you.

Now, go defeat The Kingpin!