Star Trek Online

Thanks to info from TheDude722 it was brought to my attention that this arc now only has 16 missions, down from 29 which become accessible at level 50 for Federation, Klingon and Romulan.

Your main adversary in this arc will be the Vaadwaur. Having played through this on PC and now XBOX I will say that having a strong ship will make many missions less tedious, especially since there are MANY patrol missions which require you to visit at least 3 systems all over the Delta Quadrant. I would recommend focusing your beam weapons with one type(Plasma, Phaser, Antiproton etc.). You will want your tactical consoles to boost your damage output or crit for your weapon of choice. The Vaadwaur use polaron based weapons so you will want to have your science consoles up your shield capacity and regen. Often you will see their tricobalt fields appear, this can cripple you pretty quick if you're not careful so you will want to pilot quite a bit, this isn't a head to head battle most of the time. Artillery ships can hit you hard so broadside attacks are a good strategy.

When facing them on the ground, they do have weak shields but will often face you in great numbers or send out attacks to drain your shields. Focus on the support troops buffing their allies, sometimes your attacks will have no effect if they are buffed or have a support drone close by. You shouldn't face too much difficulty unless they start pulling the strength in numbers or flank tactics.

Also, on the very last mission(Dust to Dust), without spoiling too much, when you reach the maze, don't just blast through it. There are Vaadwaur lore consoles in there if you are trying to get the accolade. There is also a purple Kobali bridge officer which can be found as well. A great person to have if you are planning on making a command based ship with your specialization.

Have fun and good luck!