The Binding of Isaac: Rebirth

In order to go to the Cathedral you have to beat Mom's Heart 11 times. Eden can only be played if you have Eden Tokens, these are obtained by fully completing a run to the lowest possible floor you have unlocked. Eden will always start with random stats, you can get a really good start or get screwed and have to rely on good items. Either way you will eventually have a good run and get these achievements easily. After Killing Isaac and touching the Chest the achievement will unlock.