The Surge

The achievement requires that you finish ANY episode with all four hardest modifiers on:

1) LEECH - player and enemies steal each other's life. No injectable use.
2) RUSH HOUR - a timer is set on Warren's life. Successful kills buy him more time.
3) EPICENTER - Every once ina while, a flame pit opens up right below Warren.
4) BLACK BELT - Dispense pain with your bare fists - and look like a real drunken master! Hitting armored body parts will wound you.

Basically: No injectables, getting hit gives enemy more life, you have no weapon and hitting armor hurts you. On top of that, you have to hurry (you have approx 3 minutes plus extra time for killed enemies) and there is the constant fire pit (you see it coming, you just need to get out of the way.

I suggest doing this on Episode one. First, get familiar with the episode.

Then the loadout - I did it with LYNX gear, full gear gives you an attack speed bonus... and well, it's light. Weapon - doesn't matter, you will be fighting with your fists. Fists are twin-rigged, if you're wondering. Not sure if increasing twin-rigged proficiency helps at all....

Implants - obviously, you won't be needing injectables, so replace all of them with other stuff. I used lots of vital boosts (give you more health) and Aggression Amplifiers (finishers replenish your health!)... just check what else you have - Auto Aid (regenerates health when near death) and Medi-Voltaicc Regulator (when health is low, regenerate health instead of energy) can be helpful, too!

1) The first area can be run through WITHOUT FIGHTING AT ALL. Just run along the tracks, be careful not to fall down where the rails are broken. A little practice and you can just sweep across the bridge without getting hit and without losing too much time.

2) The second area is a pain, but doable. Just dispense of enemies (target their unarmored parts) and avoid the fire pit. Make sure you regenerate health (by doing finishers). YOu can take the shortcut through a part of the location. When you switch of the lights and fight the two enemies, just lure them out and run past them - you don't need to kill them. If your health is low, however, kill them to regain health.

3) The real pain is the boss area. Try not to get hit by the boss, the missiles or the laser light that can take quite a lot of your health. Finish him when possible and voila!

I did this on NG++, not sure how this affects the difficulty scaling.... but by this time you will have lots of useful implants and your rig will allow more of them to be used.