The Technomancer

Save often, and run straight through. If you’ve got most of the other achievements (and I assume you’re going for extreme now or later anyway) all you have to do is the main story missions. I’d recommend the Stealth upgrades first, as often just one shotting 1 or 2 people before any fight makes it 4 times easier.

Heads up - Once you find clothes that upgrade charisma, science or crafting, keep them in your person, several challenges can be bypassed by equipping them for an easy solution.

All else fails, the very in-depth walkthrough by NicoleRenee00 is stellar and guides you through what you need step by step, though as it’s focused on getting every achievement, it does take much longer than something like a speed run.

For those struggling with combo, by far the style I’ve found the easiest is full Technomancer. Keep your shield equipped and simply use your lightning or lightning storm whenever the fluid is up, dodging around the edge of fights in the meantime. For those scenarios, the only skill you need is the ability to dodge gun shots or to simply keep dodging until their gun overheats/needs reloading.