The Witcher 3: Wild Hunt

First thing’s first, you will definitely need to grab all three ranks of Mutation’s “Acquired Tolerance” perk in the Alchemy skill tree and apply it to an empty slot in your active skill set. If you don’t have any skill points available to do this, you’ll have to purchase and consume a Potion of Clearance. This perk, as the description states, will increase your maximum Toxicity by 1 point for every known alchemy formula. By the time you’re playing this expansion, you’ll most likely have learned all the Superior variants for every bomb, oil, potion, as well as uncovered most if not all of the basic alchemy ingredients in the game. If that holds true, and it’s entirely necessary you do to an extent, your Toxicity will now be capped at or around 230 (or higher) rather than 100. 

Now to get this achievement, simply open your Inventory menu and consume seven different potions, all one right after another. Since each potion only has a Toxicity level of either 20 or 25, and sometimes 15, you won’t have to worry about exceeding the safe threshold after drinking all of them. For reference, these are the potions I used for this achievement:

• Superior Golden Oriole – 20 Toxicity
• Superior Tawny Owl – 20 Toxicitiy
• Superior Black Blood – 20 Toxicity
• Superior Blizzard – 25 Toxicity
• Superior Cat – 15 Toxicity
• Superior Petri’s Philter – 25 Toxicity
• Superior Full Moon – 25 Toxicity

As you can see, drinking these seven potions will meet the requirements for the achievement, while only raising your Toxicity by 150 points, which is still within the safe threshold. Make no mistake though…you will absolutely need to acquire all three ranks of “Acquired Tolerance” and already know several of the Superior variants to bombs, oils, and potions in order to increase the cap of your maximum Toxicity a significant amount when going for this achievement.